Fundamental & clinical pharmacology
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Fundam Clin Pharmacol · Aug 2016
Levobupivacaine attenuates lipopolysaccharide-induced acute lung injury.
Levobupivacaine (LB), a kind of local anesthetic, possesses anti-inflammatory properties. High-mobility group box 1 (HMGB1), a nuclear DNA-binding protein, plays a key role in the development of acute lung injury (ALI). The aim of this study was to investigate whether LB attenuates ALI by the inhibition of HMGB1 expression and to investigate the molecular mechanisms. ⋯ Furthermore, LB significantly inhibited LPS-induced TLR2/4 protein overexpression and NF-κB activation in the lung tissues and in LPS-stimulated A549 alveolar epithelial cells in vitro. These data indicate that LB attenuated LPS-induced ALI by the inhibition of HMGB1 expression in rats. These benefits were associated with the inhibition of TLR2/4-NF-κB pathway by LB.