International journal of geriatric psychiatry
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Int J Geriatr Psychiatry · Oct 2005
Comparative StudyA comparison of the efficacy of donepezil in Parkinson's disease with dementia and dementia with Lewy bodies.
Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) overlap in phenomenology and neurochemical deficits. We hypothesised they would not differ in their response to the cholinesterase inhibitor donepezil. ⋯ Donepezil produced similar improvements in cognition and behaviour in DLB and PDD. This supports the hypothesis that the two disorders are closely related clinically and neurobiologically. Larger scale, placebo controlled clinical trials are needed to provide an evidence base to guide the clinical use of cholinesterase inhibitors in Lewy body disease.