International journal of geriatric psychiatry
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Int J Geriatr Psychiatry · Sep 2012
Letter Randomized Controlled TrialRivastigmine in the treatment of postoperative delirium: a pilot clinical trial.
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Int J Geriatr Psychiatry · Sep 2012
Randomized Controlled TrialMemantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study.
Preclinical data suggests that memantine, a noncompetitive glutamate N-methyl- D-aspartate-receptor blocker used for the treatment of moderate to severe Alzheimer's disease, could reduce depressive and amotivated behavior occurring in the context of psychosocial stress. Therefore, we examined whether memantine could reduce depressive symptoms and amotivation manifesting in older adults after a disabling medical event, thereby improving their functional recovery. ⋯ Memantine was not associated with superior affective or functional outcome compared with placebo in medically rehabilitating older adults with depressive and apathy symptoms.