International journal of geriatric psychiatry
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Int J Geriatr Psychiatry · Apr 2015
Multicenter StudyThe relationship between changes in quality of life outcomes and progression of Alzheimer's disease: results from the dependence in AD in England 2 longitudinal study.
The relationship between conventional indicators of Alzheimer's disease (AD) progression and quality of life (QoL) outcomes is unclear. Dependence on others has been recommended as a unifying construct in defining AD severity. This study examined the relationship between indicators of disease severity (including dependence) and changes in QoL and utility over 18 months. ⋯ The natural progression of AD over 18 months does not lead to inevitable decline in QoL or utility. There are no clear or consistent direct relationships between changes in disease severity and QoL outcomes. The impact of increasing dependence and worsening disease severity is likely buffered by a combination of psychological, social and environmental factors.
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Int J Geriatr Psychiatry · Apr 2015
Review Meta AnalysisDo antipsychotics prevent postoperative delirium? A systematic review and meta-analysis.
To summarize the effect of antipsychotics for preventing postoperative delirium. ⋯ Within the limits of few randomized controlled trials, antipsychotics appeared to reduce the incidence of postoperative delirium in several surgical settings, predominantly orthopedic and for those at higher risk for delirium.