International journal of geriatric psychiatry
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Int J Geriatr Psychiatry · Jul 2015
Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset.
We examined patients with mild cognitive impairment (MCI) with a history of geriatric depression (GD) and healthy controls (HC) to evaluate the effect of beta-amyloid (Aβ) pathology on the pathology of GD by using [(18)F]florbetapir PET. ⋯ Our results showed that the rate of Aβ positivity was higher in late-onset GD and that onset-age was associated with SUVR, suggesting that the later the onset of GD, the more Aβ pathology affected its onset.