Médecine sciences : M/S
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Médecine sciences : M/S · Dec 2014
Review[Regenerative medicine of the intervertebral disc: from pathophysiology to clinical application].
A large proportion of low back pain may be explained by intervertebral disc (IVD) degeneration. Currently, the process leading to IVD degeneration highlights the pivotal role of IVD cells. ⋯ After a description of IVD physiopathology, we will develop the different strategies based on cell therapy and tissue engineering and currently under investigation to improve altered IVD degeneration. Finally, results from the current pre-clinical and clinical studies will be discussed.