Médecine sciences : M/S
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Médecine sciences : M/S · Jan 2015
Editorial Historical Article[The history of medicine: a tool to think the present].
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Médecine sciences : M/S · Dec 2014
Review[Regenerative medicine of the intervertebral disc: from pathophysiology to clinical application].
A large proportion of low back pain may be explained by intervertebral disc (IVD) degeneration. Currently, the process leading to IVD degeneration highlights the pivotal role of IVD cells. ⋯ After a description of IVD physiopathology, we will develop the different strategies based on cell therapy and tissue engineering and currently under investigation to improve altered IVD degeneration. Finally, results from the current pre-clinical and clinical studies will be discussed.
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Médecine sciences : M/S · Oct 2014
[The impact of the economic crisis on health systems of OECD countries].
This paper describes measures adopted by OECD countries in the health sector in response to the economic crisis which began in 2008: increase and diversification of revenues collected for health, increases in user charges, reductions in staff, salaries and prices of health goods and services; and policies aiming to increase health systems efficiency. It then reviews the impact of these policies on health spending trends.
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Médecine sciences : M/S · Oct 2014
Review[The growing field of immunoconjugates in oncology. A successful link(er) between antibodies and small cytotoxic molecules].
As evidenced by the recent FDA approvals of brentuximab vedotin (Adcetris(®)) and trastuzumab emtansine (Kadcyla(®)), antibody-drug conjugates (ADC) are becoming an important class of biotherapeutics in oncology. In addition, the strong pipeline of ADC in clinical development, bearing 38 ADC for the treatment of both solid and hematological malignancies, emphasizes the interest and confidence of clinicians and pharmaceutical industry in the area. ⋯ Improving the understanding of ADC mechanism of action allowed identifying the most critical factors influencing ADC efficacy and toxicity. This led to still ongoing research efforts in antibody and alternative scaffold engineering, in linker and conjugation chemistry, as well as in the screening and selection of optimal target antigens and cytotoxics.
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Médecine sciences : M/S · Oct 2014
Editorial Historical Article[Three paradoxes of the epidemic risk].