The Korean journal of internal medicine
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Korean J. Intern. Med. · Dec 2007
Benzalkonium chloride induced bronchoconstriction in patients with stable bronchial asthma.
Although benzalkonium chloride (BAC)-induced bronchoconstriction occurs in patients with bronchial asthma, BAC-containing nebulizer solutions are still being used in daily practice in Korea. The aim of this study was to evaluate the effects of inhaled aqueous solutions containing BAC. ⋯ This study suggests that the available multi-dose nebulized solution is generally safe. However, significant bronchoconstriction can occur at a relatively low BAC dose in asthmatics with severe airway responsiveness.