Brain, behavior, and immunity
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Brain Behav. Immun. · Jan 2015
The role of microglia activation in the development of sepsis-induced long-term cognitive impairment.
Oxidative stress and inflammation is likely to be a major step in the development of sepsis-associated encephalopathy (SAE) and long-term cognitive impairment. To date, it is not known whether brain inflammation and oxidative damage are a direct consequence of systemic inflammation or whether these events are driven by brain resident cells, such as microglia. Therefore, the aim of this study is to evaluate the effect of minocycline on behavioral and neuroinflammatory parameters in rats submitted to sepsis. ⋯ Treatment with minocycline prevented an increase in markers of oxidative damage and inflammation in the hippocampus after sepsis. This was associated with an improvement in long-term cognitive performance. In conclusion, we demonstrated that the inhibition of the microglia by an ICV injection of minocycline was able to decrease acute brain oxidative damage and inflammation as well as long-term cognitive impairment in sepsis survivors.
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Brain Behav. Immun. · Jan 2015
PsychoNeuroImmunology Research Society's Robert Ader New Investigator Award.
Dr. Aric A. Prather, University of California, San Francisco (UCSF), is the recipient of the 2015 Robert Ader New Investigator Award and will present on his research at the PsychoNeuroImmunology Research Society (PNIRS) meeting, June 3–6, Seattle, WA. The Robert Ader New Investigator Award is presented to an outstanding new research scientist who has made exciting basic science or clinical contributions to the field of psychoneuroimmunology.