Journal of clinical epidemiology
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The objective of this study was to determine whether standard deviations (SDs) used in sample size calculations are smaller than those found in the resulting study sample, thereby leading to underpowered studies. ⋯ Trials reporting sample size calculations for continuous endpoints published in the most reputable medical journals are often underpowered. There seems to be insufficient understanding that the SD of a sample of patients is a random variable, associated with imprecision, that cannot easily be extrapolated from one population to another.
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Review Meta Analysis Comparative Study
Short versus prolonged bed rest after uncomplicated acute myocardial infarction: a systematic review and meta-analysis.
Recently updated guidelines by the American College of Cardiology/American Heart Association and the European Society of Cardiology recommend at least 12 hours bed rest in patients with uncomplicated myocardial infarction. ⋯ We concluded that bed rest ranging from 2 to 12 days seems to be as safe as longer periods of bed rest.