Annals of biomedical engineering
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Traumatic knee injuries frequently involve the disruption of multiple ligaments, such as a complete tear of the medial collateral ligament (MCL) together with a rupture of the anterior cruciate ligament (ACL) (Miyasaka, K., D. M. Daniel, M. ⋯ Tissue Res.:2003). The knowledge gained by studying these therapeutic strategies could potentially be applied to other ligaments and tendons. In this article, antisense gene therapy to alter gene expression by using antisense oligonucleotides will be examined as a possible solution.
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Comparative Study
Physical signals and solute transport in cartilage under dynamic unconfined compression: finite element analysis.
A specialized model for charged hydrated soft tissue containing uncharged solutes (such as glucose and uncharged growth factor) was presented based on the more general, mechanoelectrochemical mixture theory (Gu et al., J. Biomech. Eng. 120:169-180, 1998: Lai et al., J. ⋯ For both permeable and impermeable loading platen cases, the electrical current density within the tissue is close to zero (approximately 10 microA/m2) except at the small region near a corner of the sample. On the radial edge of the sample, the dynamic solute flux for the large neutral solute is different from that for small neutral solute (glucose). This study is important for understanding mechanobiology of cartilage and for designing a bioreactor to be used in cartilage tissue engineering.