Nutrition
-
The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. ⋯ High protein and arginine from meat intake were associated with oxidative stress independently of genetic, lifestyle, and biochemical confounders in a population-based study. Our results suggested a novel link between high protein/arginine intake and oxidative stress, which is a major cause of age-related diseases.
-
Brain-derived neurotrophic factor (BDNF) is associated with the risk for Alzheimer's disease and type 2 diabetes. The aim of this study was to examine the association of BDNF variants with type 2 diabetes and the interactions of different BDNF genotypes with dietary habits and food and nutrient intakes in middle-aged adults. ⋯ BDNF Val/Met and Met/Met variants (rs6265) decreases the risk for glucose intolerance and type 2 diabetes. BDNF variants interacted with nutrient intake, especially energy and protein intake: Middle-aged individuals with BDNF Val/Val are prone to developing type 2 diabetes even with low energy and protein intake.
-
Comparative Study
Mortality prediction of a body shape index versus traditional anthropometric measures in an Iranian population: Tehran Lipid and Glucose Study.
A body shape index (ABSI) based on waist circumference (WC) adjusted for height and weight has been shown to be a risk factor for premature mortality. The aim of this study was to demonstrate that ABSI predicts mortality hazard better than other anthropometric measures in an Iranian population. ⋯ ABSI was the strongest predictor of all-cause mortality among the anthropometric measurements, except WHpR in women. When ABSI was added to the Framingham general cardiovascular disease algorithm, it failed to improve the predictive ability.
-
The aim of this study was to evaluate the effects of the classic ketogenic diet (KD) on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions in children and adolescents with refractory epilepsy. ⋯ KD treatment promotes negative changes in lipoprotein size and phenotype, contributing to atherogenic risk in these patients.
-
Case Reports
Hyperglycemia and subsequent torsades de pointes with marked QT prolongation during refeeding.
A fatal cardiac complication can occasionally present in malnourished patients during refeeding; this is known as refeeding syndrome. However, to our knowledge, hyperglycemia preceding torsades de pointes with QT prolongation during refeeding has not been reported. In the present study, we present a case in which hyperglycemia preceded torsades de pointes with QT prolongation during refeeding. The aim of this study was to determine the possible mechanism underlying QT prolongation during refeeding and indicate how to prevent it. ⋯ Hyperglycemia during refeeding can present with QT prolongation; consequently, monitoring blood glucose levels may be useful in avoiding hyperglycemia, which can result in QT prolongation. Furthermore, additional monitoring of QT intervals using a 12-lead electrocardiogram should allow the early detection of QT prolongation when glucose solution is administered to a malnourished patient with (severe) hypoglycemia.