Nutrition
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The aim of this study was to investigate the effects of creatine supplementation on early stages of ethanol-induced hepatic damage. ⋯ Creatine supplementation associated with ethanol is able to interfere in the alcohol metabolism and oxidative stress and to exacerbate ethanol-induced hepatic damage. These new findings are opposite to those observed in several studies where protective effects of creatine in a wide variety of injury models, including non-alcoholic fatty liver disease, were described.