Nutrition
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This real-life study is designed to investigate the short and long-term efficacy and safety of teduglutide (TED) and its effects on the quality of life (QoL) in a cohort of adult, stable patients with short bowel syndrome and chronic intestinal failure receiving long-term parenteral support (PS). ⋯ This real-world experience allows us to state that, after 48 months of treatment, TED: 1) is a safe therapy with minimal, rare side effects; 2) produces a rapid reduction in PS volumes in 40% of treated patients; 3) consents 20% of enrolled patients to be weaned off PS; 4) maintains a stable nutritional state and, finally, 5) significantly improves the QoL.
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This randomized clinical trial was conducted to investigate the effects of personalized nutrition counseling according to blood glucose response and dietary intake, which can be measured using a flash continuous glucose monitoring (CGM) device, on weight changes and eating habits in obese adults. The participants of this study comprised obese adults over 30 years of age, which were randomly assigned to either the (1) personalized nutrition group (PN) or (2) control group (CON) with a study period of up to 12 weeks. Body weight, body mass index, body fat mass, body fat percentage, and waist-to-hip ratio significantly decreased in the PN group when compared with the CON group (P < 0.05; P < 0.01). ⋯ The levels of blood HbA1c and insulin were significantly decreased in both groups, but the PN group showed a greater decrease (HbA1c, P = 0.000; insulin, P = 0.000) than the CON group did (HbA1c, P = 0.001; insulin, P = 0.001). The blood triglyceride levels were significantly lowered only in the PN group (P = 0.026). It was confirmed that personalized nutrition counseling using a flash CGM device was effective in reducing body weight, abdominal fat, and blood HbA1c, insulin, and triglyceride levels and improving meal quantity and eating habits in obese adults.
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Inulin is a plant polysaccharide that may affect the gut barrier depending on its degree of polymerization (DP). Therefore, this study aimed to determine the effect of dietary level of two inulin types differing in DP on mucin content and MUC gene expression in the colon mucosa of pigs. ⋯ Inulin, particularly with higher DP, may exert a beneficial effect on the colon mucosa by modulation of MUC gene expression.
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The therapeutic potential of vitamin D has been studied regarding adjuvant interventions. Some studies have evaluated the factors associated with vitamin D deficiency (VDD) in healthy populations, but they are scarce in children and adolescents with type 1 diabetes mellitus (T1DM). The objective of this study was to describe the prevalence of and factors associated with VDD in children and adolescents with T1DM. ⋯ A high prevalence of VDD was observed as well as some associated lifestyle and clinical variables. Recommendations for children and adolescents with T1DM include monitoring their 25(OH)D and encouraging healthy eating practices and routine physical exercise.
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Malnutrition in stroke is associated with poor clinical outcomes. Bioelectrical impedance analysis-derived phase angle (PhA) is widely used for assessing nutritional status as an index of muscle quality. This study aimed to evaluate the associations between whole body and limb PhAs and nutritional risk in stroke patients. PhA predictors were also identified. ⋯ In stroke patients, low PhA values were associated with high nutritional risk. PhA at the beginning of rehabilitation may serve as a reliable parameter to be considered in the evaluation of nutritional status.