The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
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Within-city variation in air pollution has been associated with childhood asthma development, but findings have been inconsistent. We examined whether perinatal air pollution exposure affected asthma onset during "pre-school and "school age" periods in a population-based birth cohort.65,254 children born between 1999 and 2002 in the greater Vancouver metropolitan region were followed until age 10 years using linked administrative health databases. Asthma cases were sex- and age-matched to five randomly chosen controls. ⋯ Enhanced impacts were observed amongst low-term-birthweight cases. Associations were independent of surrounding residential greenness. Within-city air pollution variation was associated with new asthma onset during the pre-school years.