European journal of clinical nutrition
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Randomized Controlled Trial Clinical Trial
Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage.
Various mechanisms have been proposed to explain the association between plasma total homocysteine (tHcy) and risk of cardiovascular disease, including oxidative activity of homocysteine. ⋯ In healthy individuals lowering plasma tHcy does not have any functional implications regarding oxidative damage.