Synapse
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We examined the acute effect of the irreversible GABA-transaminase inhibitor, gamma-vinyl GABA (GVG, Sabril((R)), Vigabatrin((R))) on increases in nucleus accumbens (NAc) dopamine (DA) following acute administration of methamphetamine, heroin, or ethanol. Methamphetamine (2.5 mg/kg) produced a dose-dependent increase (2, 700%) in NAc DA. GVG preadministration (300 or 600 mg/kg), however, inhibited this response by approximately 39 and 61%, respectively. ⋯ Finally, at half the dose necessary for heroin, GVG (150 mg/kg) also completely abolished ethanol-induced increases in NAc DA following a 0.25 g/kg challenge dose (140%). Taken with our previous findings using nicotine or cocaine as the challenge drug, these results indicate that GVG attenuates increases in NAc DA by a mechanism common to many drugs of abuse. However, it appears unlikely that an acute dose of GVG can completely inhibit increases in NAc DA following challenges with a drug whose mechanism of action is mediated primarily through the DA reuptake site.
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ERRATUM: Everett A. W. 1999. Membrane Recycling Due to Low and High Rates of Nerve Stimulation at Release Sites in the Amphibian (Bufo marinus) Neuromuscular Junction. ⋯ In the above-referenced article, Figure 1 was erroneously reproduced in black and white as converted from a color original, not providing an accurate representation of the staining. The figure is reproduced here as the author intended, from an original black and white rendering. The Publisher sincerely apologizes for this error.