Journal of investigative surgery : the official journal of the Academy of Surgical Research
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Biography Historical Article
Samuel D. Gross: the nestor of American surgery.
Samuel David Gross (1805-1884) represented the most notable surgeon of his generation and was honored with the title of "The Nestor of American Surgeon" by surgeon biographer Isaac Minis Hays. Of Pennsylvania Dutch stock, he was born on the family farm near Easton, Pennsylvania. He attended Wilkebarré Academy and Lawrenceville High School, noted private institutions of the day. ⋯ History values him as a hard working, honest, highly competent, and committed individual. His capacity for work and his dedication to a single cause were unrivaled. Doctor Gross integrated the best that surgery could give to future generations of surgical professionals.
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Mesenteric ischemia is a devastating disease process that frequently challenges clinicians. To enhance the early diagnosis of gut ischemia and judgment of its severity, it may be helpful to detect the unusual existence or increase in biomarkers in the body fluid. The aim of the present study was to evaluate the correlation of plasma nitric oxide (NO) and endothelin-1 (ET-1) levels to mesenteric ischemia using an animal model. ⋯ In addition, ischemic intestinal injury was confirmed by the significantly elevated histological scores in the AMI group after 60 min of ischemia (p < .001). Our preliminary results suggest the possibility of important insights regarding NO and ET-1 changes into the mechanism of pathogenesis in AMI in rats. The increases in plasma NO and ET-1 levels may potentially be noninvasive biomarkers for the early detection of this disease.