Journal of investigative surgery : the official journal of the Academy of Surgical Research
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We tested various doses of MgSO(4) to investigate the effect of Mg on a spinal cord ischemia. ⋯ Intravenous MgSO(4) with low or medium dose (30, or 100 mg/kg) did not improve neurological injury following spinal cord ischemia. Furthermore, higher dose of MgSO(4) (300 mg/kg) resulted in hemodynamic instability and aggravated neurologic outcome.
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The scientific surgeon begins with Joseph Lister and his seminal work on the development of antiseptic surgery published in 1867 in Lancet. No other significant works of the times compare to Lister's contributions in this particular field of surgery. Lister utilized pristine scientific principles, learned in part from Pasteur, to understand and apply the germ theory of disease to practical surgery. ⋯ The scientific surgeon is now well integrated and fully based on the science applied to surgery. Halsted's surgery was reproduced by other programs; and with time uniformity was established by all programs offering surgical residencies in the United States and many other parts of the world. The scientific surgeon is a firm reality at this point.