Journal of investigative surgery : the official journal of the Academy of Surgical Research
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Comparative Study
Comparison of two gelatin and thrombin combination hemostats in a porcine liver abrasion model.
Surgical hemostasis is achieved using adjunctive hemostats when conventional methods fail. ⋯ Smooth gelatin has an increased ability to retain thrombin and RBC's in vitro which may explain why it provides superior hemostatic effectiveness, superior control of bleeding, and greater reduced blood loss in vivo.
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The involvement of voltage-dependent calcium channels and reactive oxygen species in the pathophysiology of neuropathic pain might justify the preventative administration of antioxidant enzymes, at low doses, in combination with gabapentin (GaP) to maximize its analgesic effect in an experimental model of neuropathic pain in rats. ⋯ These results suggest that preventive antioxidants in combination with GaP provided a synergistic suppression of thermal hypersensitivity that GaP alone cannot produce.