Journal of investigative surgery : the official journal of the Academy of Surgical Research
-
Biography Historical Article
Birth of scientific surgery. John Hunter versus Joseph Lister as the father or founder of scientific surgery.
John Hunter (1728-1793) has frequently been considered the "Father or Founder of Scientific Surgery". His inscription at Westminster Abbey presents him as "a gifted interpreter of the Divine Power and wisdom at work in the laws of organic life and the Founder of Scientific Surgery." I take issue with Hunter being considered the father or founder of scientific surgery and propose Joseph Lister (1827-1912) as the one who should receive this consideration. Hunter was a skilled surgeon, an inquisitive innovator, keen observer, great naturalist, and astute thinker, who made no surgical discoveries of any transcendence to the discipline. ⋯ Therefore, he should not be considered the "Father or Founder of Scientific Surgery." On the contrary, Lister became a revolutionary scientific innovator by explaining the pervasive role of microorganisms in surgical wounds. His work directly affected surgery and its role in medicine. Lister, therefore, should be considered the "Father or Founder of Scientific Surgery."
-
Randomized Controlled Trial
Ventilation during cardiopulmonary bypass: impact on neutrophil activation and pulmonary sequestration.
Cardiopulmonary bypass (CPB) is associated with neutrophil activation, pulmonary sequestration, and release of inflammatory mediators leading to pulmonary dysfunction. We investigate the effect of continuous ventilation during cardiopulmonary bypass on neutrophil activation and pulmonary sequestration. ⋯ Cardiopulmonary bypass during coronary artery bypass grafting is associated with increased neutrophil pulmonary sequestration, and blood neutrophil CD11b activation. Continuous ventilation during cardiopulmonary bypass does not significantly reduce neutrophil pulmonary sequestration or activation.
-
Comparative Study
Improvement of the tissue-adhesive and sealing effect of fibrin sealant using polyglycolic acid felt.
Although fibrin sealant (FS) has an advantage of high biocompatibility, its adhesive force and sealing effect have been generally considered to be inadequate. In the present study, a high adhesive force and sealing effect were obtained by first rubbing fibrinogen solution into the target tissue, attaching polyglycolic acid (PGA) felt to the treated area, and finally spraying it with FS. This method was compared with three conventional FS application methods and a method using fibrin glue-coated collagen fleece. ⋯ The high adhesive force of FS with PGA felt seemed to be due the high fibrin content of the fibrin gel (FG). Light and electron microscopic observations suggested that the formation of FG in closer contact with the muscle fibers was a factor contributing to this superior adhesive force. Comparison of the sealing effect of the present method with other methods using various biomaterials in combination with FS showed that the sealing effect of FS with PGA felt was 1.4 times higher that of polyglactin 910, 1.8 times that of polytetrafluoroethylene, and 6.7 times that of oxidized regenerated cellulose.
-
This study was designed to evaluate the role of different intravascular volume replacement regimens of HES 130/0.4 on wound healing process in left colonic anastomoses in the presence of intra-abdominal sepsis induced by murine model of cecal ligation and puncture (CLP). ⋯ This study showed that moderate doses (15 ml/kg) of HES 130/0.4 administration significantly prevented this intraperitoneal sepsis-induced impaired anastomotic healing of the left colon. It also suggested the possibility of poorer anastomotic healing receiving HES at higher doses (30 ml/kg). Clearly, HES 130/0.4 now should not be recommended to use at a high doses postoperatively in sepsis.