Current opinion in infectious diseases
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Curr. Opin. Infect. Dis. · Aug 2005
ReviewChanging face of health-care associated fungal infections.
The purpose of this review was to evaluate recent publications on the epidemiology, diagnosis and management of invasive fungal infections. ⋯ Recent data suggest that the epidemiology of invasive fungal infections may be changing with the emergence of uncommon molds and the occurrence of invasive aspergillosis in 'nonclassical' immunocompromised hosts. New diagnostic tools and improved antifungal agents are available to facilitate early diagnosis and offer new treatment options.
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Curr. Opin. Infect. Dis. · Aug 2005
ReviewUpdate on Pseudomonas aeruginosa and Acinetobacter baumannii infections in the healthcare setting.
Infections with Pseudomonas aeruginosa and Acinetobacter baumannii are of great concern for hospitalized patients, especially with multidrug-resistant strains. This review focuses on recent data that may help us to understand the emergence, spread, and persistence of antibiotic resistance, and summarizes the optional treatment feasible for these resistant bacteria. ⋯ The emergence and spread of multidrug-resistant P. aeruginosa and A. baumannii and their genetic potential to carry and transfer diverse antibiotic resistance determinants pose a major threat in hospitals. The complex interplay of clonal spread, persistence, transfer of resistance elements, and cell-cell interaction contribute to the difficulty in treating infections caused by these multidrug-resistant strains. In the absence of new antibiotic agents, new modalities of treatment should be developed.