Current opinion in infectious diseases
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Curr. Opin. Infect. Dis. · Dec 2007
ReviewImpact of pharmacodynamics and pharmacokinetics on echinocandin dosing strategies.
Studies of antibiotic pharmacokinetics and pharmacokinetic-pharmacodynamics are useful in the design of optimal dosing strategies. This review examines recent advances in echinocandin pharmacokinetics and pharmacodynamics, and discusses how these studies could lead to newer dosing strategies for the treatment of invasive candidiasis. ⋯ A better understanding of caspofungin, micafungin, and anidulafungin pharmacokinetic-pharmacodynamics will help in the design of new optimized dosing regimens for invasive candidiasis.