Gynecologic oncology
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Gynecologic oncology · Mar 2001
Review Case ReportsTamoxifen as systemic treatment of advanced breast cancer during pregnancy--case report and literature review.
When patients with metastatic breast cancer become pregnant, management is complicated by the potential harms of drug treatment to the fetus and by the potential effects of the pregnancy on the cancer. Chemotherapy is considered optimal systemic anti-cancer therapy from the second trimester, while tamoxifen has been considered inappropriate due to concerns over possible teratogenesis and lack of efficacy. ⋯ The use of tamoxifen in pregnancy is complex, but is not necessarily associated with fetal harm and may be considered a therapeutic option in selected cases.