Current opinion in immunology

The most recent articles from: August 2012

  • Curr. Opin. Immunol. · Aug 2012

    Review

    Immune senescence and vaccines to prevent herpes zoster in older persons.

    Varicella-zoster virus (VZV) T-cell-mediated immunity (VZV-CMI) in older persons prevents latent VZV in sensory neurons from reactivating to cause herpes zoster. VZV-CMI declines greatly with aging, but can be restored by the licensed zoster vaccine. ⋯ To understand these aging effects, limited information about the phenotypic and functional differences in VZV-CMI in old and young persons are reviewed, as well as the reversal of these differences by vaccination. Based on information from these studies some potential approaches to improving prevention of herpes zoster are discussed.

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