BMJ : British medical journal
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Review Meta Analysis
Systematic review of topical capsaicin for the treatment of chronic pain.
To determine the efficacy and safety of topically applied capsaicin for chronic pain from neuropathic or musculoskeletal disorders. ⋯ Although topically applied capsaicin has moderate to poor efficacy in the treatment of chronic musculoskeletal or neuropathic pain, it may be useful as an adjunct or sole therapy for a small number of patients who are unresponsive to, or intolerant of, other treatments.
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To determine the efficacy and safety of topical rubefacients containing salicylates in acute and chronic pain. ⋯ Based on limited information, topically applied rubefacients containing salicylates may be efficacious in the treatment of acute pain. Trials of musculoskeletal and arthritic pain suggested moderate to poor efficacy. Adverse events were rare in studies of acute pain and poorly reported in those of chronic pain. Efficacy estimates for rubefacients are unreliable owing to a lack of good clinical trials.
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Randomized Controlled Trial Comparative Study Clinical Trial
Effectiveness of nicotine patches in relation to genotype in women versus men: randomised controlled trial.