Head & neck
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Randomized Controlled Trial
Two-year follow-up of a randomized phase III clinical trial of nivolumab vs. the investigator's choice of therapy in the Asian population for recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141).
The present study evaluated the 2-year survival of the Asian population in the CheckMate 141 trial. ⋯ NCT02105636.
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Randomized Controlled Trial
Intraoperative goal-directed hemodynamic management in free tissue transfer for head and neck cancer.
The purpose of this study was to determine the effect of algorithmic physiologic management on patients undergoing head and neck free tissue transfer and reconstruction. ⋯ The goal-directed hemodynamic management algorithm decreased the ICU length of stay. Judicious use of vasoactive drugs and goal-directed fluid administration has a role in improving perioperative outcomes for patients undergoing head and neck free tissue transfer. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1974-E1980, 2016.
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Randomized Controlled Trial
Prospective, randomized controlled trial on use of ropivacaine after robotic thyroid surgery: Effects on postoperative pain.
We evaluated the effects of ropivacaine for pain relief after robotic thyroid surgery. ⋯ Ropivacaine instillation after robotic thyroid surgery reduces acute postoperative pain and analgesic requirements without adverse events. © 2015 Wiley Periodicals, Inc. Head Neck 38: E-E, 2016.
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Randomized Controlled Trial Multicenter Study Comparative Study
Randomized phase III study of 2 cisplatin-based chemoradiation regimens in locally advanced head and neck squamous cell carcinoma: impact of changing disease epidemiology on contemporary trial design.
Chemoradiotherapy results in excellent outcomes in locally advanced head and neck squamous cell carcinoma (HNSCC). This trial compared 2 chemoradiotherapy regimens. ⋯ Multiagent was not superior to single-agent chemoradiotherapy. Overrepresentation of HPV/p16+ patients resulted in better than expected outcomes.
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Randomized Controlled Trial Comparative Study
Pain and surgical outcomes with and without neck extension in standard open thyroidectomy: a prospective randomized trial.
The purpose of this study was to compare surgical outcomes between those patients who underwent open thyroidectomy with and without neck extension. ⋯ Compared to group I, pain on postoperative day 1 and at the first visit in group II were significantly less, but both groups had similar overall RLN injury rate.