Phytotherapy research : PTR
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Randomized Controlled Trial
Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis.
The safe and efficacious use of Pycnogenol (French maritime pine bark extract) in other inflammatory diseases prompted this study of its antiinflammatory effects in patients with osteoarthritis (OA). The aim of the study was to evaluate whether Pycnogenol reduces the symptoms of OA in a double-blind, placebo-controlled, randomly allocated trial with patients suffering from knee osteoarthritis stages I and II. ⋯ Results show that Pycnogenol in patients with mild to moderate OA improves symptoms and is able to spare NSAIDs.