Phytotherapy research : PTR
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Many transient receptor potential (TRP) channels are activated or blocked by various compounds found in plants. TRPV1 (transient receptor potential vanilloid 1) and transient receptor potential ankyrin 1 (TRPA1) are members of the TRP ion channel family which are implicated as cough receptors. Several plant extracts are used in traditional Chinese medicine (TCM) for the treatment of cough. ⋯ Only UA tested at 100 μM showed potent antagonistic activity towards TRPV1. Both PM and PN had no activity when tested alone, however, both were able to enhance the UA effect. A similar, but less marked, inhibition was also noted for TRPA1.