Journal of internal medicine
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Comparative data of non-vitamin K antagonist oral anticoagulants (NOAC) are lacking in patients with atrial fibrillation (AF). ⋯ Standard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.
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Meta Analysis
Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts.
Subclinical hyperthyroidism (SHyper) has been associated with increased risk of hip and other fractures, but the linking mechanisms remain unclear. ⋯ Amongst adults, SHyper was associated with increased femoral neck bone loss, potentially contributing to the increased fracture risk.