Journal of internal medicine
-
Diabetes mellitus is linked to premature mortality of virtually all causes. Furin is a proprotein convertase broadly involved in the maintenance of cellular homeostasis; however, little is known about its role in the development of diabetes mellitus and risk of premature mortality. ⋯ Individuals with high plasma furin concentration have a pronounced dysmetabolic phenotype and elevated risk of diabetes mellitus and premature mortality.
-
Although biofilms have been observed early in the history of microbial research, their impact has only recently been fully recognized. Biofilm infections, which contribute to up to 80% of human microbial infections, are associated with common human disorders, such as diabetes mellitus and poor dental hygiene, but also with medical implants. The associated chronic infections such as wound infections, dental caries and periodontitis significantly enhance morbidity, affect quality of life and can aid development of follow-up diseases such as cancer. ⋯ Although basic principles of biofilm formation have been deciphered, the molecular understanding of the formation and structural organization of various types of biofilms has just begun to emerge. Basic studies of biofilm physiology have also resulted in an unexpected discovery of cyclic dinucleotide second messengers that are involved in interkingdom crosstalk via specific mammalian receptors. These findings even open up new venues for exploring novel anti-biofilm strategies.
-
The above letter to the editor written by "Lars Andersson" (stated to be affiliated with Department of Physiology and Pharmacology, Karolinska Institutet), published in print and online in the Journal of Internal Medicine in Wiley Online Library https://onlinelibrary.wiley.com) on the date given above, has been retracted by agreement between the journal's Editor-in-Chief Ulf de Faire, the Association for Publication of the Journal of Internal Medicine and John Wiley & Sons Limited. The retraction has been agreed due to the author's use of what appears to be a false name and affiliation. ⋯ Response on the author's reply to the Letter to the Editor: contradictory data on type 1 diabetes in a recently published article: risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix. J Intern Med 2015; 277: 272-3.
-
Whether a causal relationship exists between milk intake and reduced risk of fractures is unclear. ⋯ Genetically lifelong lactase persistence with high milk intake was not associated with hip fracture in Danish population-based cohorts. A meta-analysis combining Danish studies with published Northern European population studies also showed that lactase persistence was not associated with fracture risk. Genetic lactase persistence was associated with a higher femoral neck BMD, but not lumbar spine or total hip BMD.
-
Multicenter Study Observational Study
Hyponatremia and activation of vasopressin secretion are both independently associated with 30-day mortality: results of a multicenter, observational study.
Hyponatremia is a common feature of acute illness and associated with increased mortality. This may be explained by a stress-mediated activation of the vasopressin system with an increase in free-water reabsorption. ⋯ This prospective study including medical patients upon emergency room admission found hyponatremia as well as an activation of the vasopressin system to be independently associated with mortality. This suggests that stress- and vasopressin-independent mechanisms are responsible for the association of low sodium levels with mortality.