Journal of anesthesia
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Journal of anesthesia · Jun 1998
A comparison between sevoflurane and propofol when combined with continuous epidural blockade in adult patients.
The effects of sevoflurane and propofol, in combination with continuous epidural blockade, on blood pressure control and time of recovery from anesthesia were compared. ⋯ Propofol anesthesia, in combination with continuous epidural blockade, results in more stable intraoperative hemodynamics than sevoflurane anesthesia, but requries a longer recovery time and results in larger interindividual variability than sevoflurane anesthesia.
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Journal of anesthesia · Jun 1998
Effects of KRN2391-induced hypotension on the endocrine system and carbohydrate metabolism in halothane-anesthetized dogs.
The hemodynamic profiles of KRN2391-induced hypotension have been reported to be a hyperdynamic state. However, the endocrine effects of KRN2391-induced hypotension remain to be elucidated. We investigated the endocrine and metabolic effects of KRN2391-induced hypotension on the plasma concentrations of catecholamines, aldosterone, cortisol, glucose, and lactic acid and on plasma renin activity. ⋯ KRN2391-induced hypotension activates the sympathetic nervous system and consequently may modulate the renin-angiotensin-aldosterone axis and carbohydrate metabolism.
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Journal of anesthesia · Jun 1998
Muscle lactate concentration during experimental hemorrhagic shock.
Blood lactate concentration does not correspond well to oxygen transport variables during circulatory shock. Prolonged washout of lactate from tissues during shock has been reported. This study was designed to test the hypothesis that the discrepancy between serum lactate and oxygen metabolism is caused by the failure of lactate to wash out from the tissues and that tissue lactate may reflect the oxygen metabolism better. ⋯ In the setting of experimental hemorrhagic shock, only tissue lactate levels reflected the true deficit in oxygen metabolism. The difference between lactate levels in muscle and serum represented the severity of the shock.