Journal of anesthesia
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Journal of anesthesia · Jun 2013
High-dose remifentanil increases blood pressure and heart rate mediated by sympatho-activation in conscious rats.
The ultra-short-acting μ-opioid receptor agonist, remifentanil, is commonly used in clinical anesthesia; however, there are limited data about the hemodynamic effects of remifentanil itself without anesthetics. We investigated the effects of an ultra-short-acting μ-opioid receptor agonist, remifentanil, on cardiovascular and sympathetic function in conscious rats. ⋯ High-dose remifentanil decreases MAP and HR transiently and increases these parameters mediated by the activation of sympathetic nerve activity in conscious rats.
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Journal of anesthesia · Jun 2013
Propofol attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production through p38 MAPK and SAPK/JNK in alveolar epithelial cells.
Propofol is widely used in sedation and surgical procedures involving patients with acute lung injury (ALI), a common complication in critically ill patients. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in pathological changes in ALI. The present study investigated the anti-inflammatory effect and mechanism of propofol on MCP-1 production and mitogen-activated protein kinase (MAPK) phosphorylation induced by lipopolysaccharide (LPS) in alveolar epithelial cells (AECs). ⋯ Propofol at clinically relevant concentrations attenuated LPS-induced MCP-1 mRNA expression and secretion by inhibiting the phosphorylation of p38 MAPK, SAPK/JNK, ATF-2, and c-Jun exerting its anti-inflammatory effects in AECs. These results suggest that propofol may modulate inflammatory response at clinically achievable concentrations in ALI.
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Journal of anesthesia · Jun 2013
Retraction Of PublicationRetraction note: Further notice of formal retraction of articles by Dr. Yoshitaka Fujii.
Retraction to: J Anesth (1997) 11:126–129DOI 10.1007/BF02480074,J Anesth (1996) 10:22–25DOI 10.1007/BF02482063,J Anesth (1996) 10:176–180DOI 10.1007/BF02471386,J Anesth (1995) 9:58–60DOI 10.1007/BF02482037,J Anesth (1995) 9:343–347DOI 10.1007/BF02479949,J Anesth (1994) 8:301–304DOI 10.1007/BF02514655. To readers of the Journal of Anesthesia: In addition to the articles listed in a retraction note in JAnesth (2013) 27:322, the following articles published by Dr. Yoshitaka Fujii in the Journal of Anesthesia also are hereby retracted as a result of: (1) overwhelming evidence of fabrication related to the fact that the distributions of many variables reported by Dr. ⋯ J Anesth. 1996;10:22–5.*Fujii Y, Toyooka H. Nicardipine inhibits amrinone-enhanced contractility in fatigued diaphragm. J Anesth.1997;11:126–9.