Journal of anesthesia
-
Journal of anesthesia · Feb 2015
Randomized Controlled TrialDezocine pretreatment prevents myoclonus induced by etomidate: a randomized, double-blinded controlled trial.
The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effects of dezocine on the incidence and severity of myoclonus induced by etomidate. Patients (108) were randomly assigned to one of two groups to receive either 0.1 mg kg(-1) of dezocine (n = 54; Group D) or saline (n = 54; Group S) intravenously 1 min before 0.3 mg kg(-1) etomidate was given. ⋯ The incidence and the intensity of myoclonus were significantly lower in Group D (0 %) than in Group S (75.9 %) (P < 0.01), and all patients showed stable cardiovascular profiles. The results suggest that infusion of 0.1 mg kg(-1) dezocine 1 min before etomidate administration is effective for suppressing myoclonus induced by etomidate during induction of general anesthesia without significant side-effects.
-
Journal of anesthesia · Feb 2015
The accuracy of non-invasively continuous total hemoglobin measurement by pulse CO-Oximetry undergoing acute normovolemic hemodilution and reinfusion of autologous blood.
Non-invasively continuous total hemoglobin (SpHb) measurement has not been assessed adequately in acute bleeding and rapid blood transfusion during surgery. Thus, we have assessed the efficacy of SpHb during both acute normovolemic hemodilution (ANH) and autologous blood transfusion (ABT). ⋯ The present data suggest that SpHb may overestimate tHb during ANH and ABT. In addition, PI and tHb levels had an impact on the accuracy of SpHb measurements.
-
Journal of anesthesia · Feb 2015
Effect of three peptidase inhibitors on antinociceptive potential and toxicity with intracerebroventricular administration of dynorphin A (1-17) or (1-13) in the rat.
The N- and C-terminal regions of dynorphin (Dyn) A (1-17) activate opioid and N-methyl-D-aspartate receptors, respectively. Earlier studies demonstrated that Dyn-converting enzyme cleaved Dyn A (1-17) mainly at the Arg(6)-Arg(7) bond, resulting in the production of N- and C-terminal region peptide fragments, and that this enzyme was not inhibited by a mixture of the three peptidase inhibitors (PIs) amastatin (A), captopril (C), and phosphoramidon (P). The purpose of the present study was to evaluate antinociceptive potential and toxicity with intracerebroventricular administration of Dyn A (1-17) or (1-13) under pretreatment with a mixture of A, C, and P and/or Dyn-converting enzyme inhibitor (p-hydroxymercuribenzoate). ⋯ These findings suggest that administration of a mixture of the three PIs increases Dyn A (1-17)- or (1-13)-induced antinociception under physiological conditions without toxicity.
-
Journal of anesthesia · Feb 2015
ReviewDexmedetomidine: a review of applications for cardiac surgery during perioperative period.
Cardiac surgery is associated with a high incidence of cardiovascular and other complications during the perioperative period that translate into increased mortality and prolonged hospital stays. Safe comprehensive perioperative management is required to eliminate these adverse events. ⋯ Although there are some side effects of dexmedetomidine, it is emerging as an effective therapeutic agent in the management of a wide range of clinical conditions with an efficacious, safe profile. The present review serves as an overview update in the diverse applications of dexmedetomidine for cardiac surgery during the perioperative period.
-
Journal of anesthesia · Feb 2015
Letter Case ReportsRepetitive severe hypotension induced by indigo carmine.