Der Schmerz
-
Case Reports
[DRESS syndrome : Rare and potentially lethal allergic reaction to carbamazepine-a case report].
A 64-year-old man with chronic low back pain had been treated with tramadol, meloxicam and metamizole for several years. Due to additional neuropathic pain in the lower extremities, the medication was complemented with carbamazepine. After 5 weeks of treatment, the patient developed maculopapulose exanthema and fever, followed by hepatitis, leukocytosis and eosinophilia. ⋯ The previously diagnosed neuropathic pain syndrome cannot be verified. After appropriate modification of therapy, the patient's pain perception was significantly reduced, allowing for complete withdrawal of pain-relieving medication. This case report illustrates that merely pharmacological treatment of chronic pain syndromes bears only little prospect of success but increased risk of side effects.
-
Small molecules can have a significant effect on human metabolic processes. Computational drug design aims at constructing specialized small molecules that selectively and efficiently address specific proteins. ⋯ Modern computational drug design goes far beyond the lock and key principle. Possible future developments are discussed and a current successful example of computational drug design in the field of painkiller medication is demonstrated.
-
Biography Historical Article
[Development of epidural spinal cord stimulation : Fortieth anniversary of the first implantation in Germany].
Spinal cord stimulation is nowadays an established therapy for various neuropathic and vasculopathic pain syndromes after more conservative measures have failed. However, 40 years ago, only 5 years after the first worldwide implantation in the US, this therapy was promoted in Germany. ⋯ Nowadays about 1700 spinal cord stimulation systems are implanted annually in Germany. The development of spinal cord stimulation from the beginnings up to now taking into special consideration the early years in Germany are presented.
-
Pain sensitivity is a risk factor for postoperative pain and is usually determined by experimental pain stimulation. Ruscheweyh et al. (Pain 146:65-74, 2009) developed the pain sensitivity questionnaire (PSQ) which assesses general pain sensitivity by self-rating without using extensive and painful experimental stimulation. The objective of this study was to examine whether subjective pain sensitivity affects postoperative pain intensity and can be considered as a risk factor for postoperative pain. ⋯ Subjective pain sensitivity can easily be measured by the PSQ and is a risk factor for postoperative pain intensity.