Der Schmerz
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Complex regional pain syndrome (CRPS) is a severe pain disorder with an unclear pathophysiology. Biomarkers offer opportunities to enhance diagnosis, stratification, prognosis, and monitoring. Serum markers such as cytokines and microRNAs show potential but require further research. ⋯ Psychosocial factors, including pain intensity and psychological comorbidities, are important prognostic indicators. Future research should focus on specific biomarkers to develop mechanism-based treatments. A multidisciplinary approach remains crucial for effective treatment.
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Complex regional pain syndrome (CRPS) is often associated with severe mental impairments. Initial pain-related fears in particular appear to be negative predictors for long-term therapy results. Procedures for cognitive behavioral therapy are an important component of treatment. ⋯ Behavioral analyses are used to uncover dysfunctional coping patterns, such as a fear avoidance coping strategy. In this case the use of graded activity treatment approach is indicated, in which the activity level is gradually increased. In the transfer phase psychotherapy supports affected patients in (re)designing their professional and private environments.
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Health services research looks at a form of care under contextual conditions. Often, and especially in the treatment of recurrent or chronic pain, these forms of care are complex interventions. Ensuring internal validity for subsequent interpretability of the results achieved as an essential requirement for studies in health services research therefore presents researchers with the challenge that they have to develop complex study protocols and implement and monitor them in clinical care. ⋯ On the one hand, health services research provides appropriate recommendations for the planning, implementation and evaluation of studies on complex interventions under contextual conditions, which can be of great importance for further research into the effectiveness of IMST. On the other hand, experience from interdisciplinary pain research can also help to successfully plan and conduct studies on complex interventions. This article introduces the understanding of interdisciplinarity (and interprofessionalism) in pain medicine and research, outlines possible key points for study planning and implementation using the example of two health services research studies and concludes by discussing gaps in research on interdisciplinary collaboration in pain medicine and research.