Annals of medicine
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Whole brain radiotherapy (WBRT) is the mainstay of treatment for patients with non-small cell lung cancer (NSCLC) with multiple brain metastases (BMs); however, the BRAIN study showed that the efficacy of WBRT is unsatisfactory. This prospective phase II study aimed to evaluate the efficacy and safety of WBRT combined with anlotinib, a novel anti-angiogenic multi-target tyrosine kinase inhibitor (TKI), in patients with multiple BMs (>3) from advanced NSCLC. ⋯ Anlotinib combined with WBRT is effective and well-tolerated in patients with NSCLC with multiple BMs.
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To analyze the factors influencing myopia and construct a nomogram to forecast the risk of myopia among school-age children, providing a reference for identifying high-risk groups to aid prevention and control. ⋯ The nomogram was accurate in predicting the risk of myopia among schoolchildren. This study provides a reference for screening high-risk students and for individualized myopia prevention and control.
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Comparative Study
Comparison of two platinum-containing chemotherapy regimens in the treatment of advanced cervical cancer with concurrent chemoradiotherapy.
The present study aims to compare the efficacy and side effects of a platinum-containing combination regimen and platinum single-drug concurrent chemoradiotherapy (CCRT) in patients with advanced cervical cancer (CC) and to understand the prognostic factors in patients with CC. ⋯ A higher patient age, having an AC and stage of IIIa and a high SCC-Ag value before treatment resulted in a relatively low survival rate.
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Providing the highest quality care with no biases is the goal of every healthcare system. As a part of that goal hospital readmission has been investigated due to its impact on healthcare cost and case fatality rate in patient outcome. Patient's demographics, substance use and insurance barriers have been investigated as factors for readmission rate but the impact of COVID-19 pandemic on those biases and barriers have not been studied extensively yet. ⋯ Our multivariable analysis showed that the rate of readmissions during the COVID-19 pandemic was statistically higher among substance users (p = 0.003) and Medicaid insured (p = 0.038), and less likely among Spanish speakers p = 0.003. This study is limited due to small sample size and does not accurately represent the full population of the United States. Our hope is to further investigate the impact of COVID-19 pandemic on the readmission rate and to identify any influencing factors, biases, and barriers that contributed to the increased rate of readmission to learn and avoid future readmissions during straining times in medicine such as during COVID-19 pandemic.
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Observational Study
Clinical efficacy of dienogest against endometriomas with a maximum diameter of ≥4 cm.
This prospective observational study aims to demonstrate the clinical efficacy of dienogest in treating endometriomas with a maximum diameter of ≥4 cm. ⋯ Dienogest could effectively reduce the diameter and volume of endometriomas with a maximum diameter of ≥4 cm, improving anemia, as well as pain symptoms and preserving ovarian function.