Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
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Comparative Study
Allergen-induced bronchial inflammation is associated with decreased levels of surfactant proteins A and D in a murine model of asthma.
Increasing evidence suggests that pulmonary surfactant protein A (SP-A) and D (SP-D) participate in the lung defence against pathogens. However, the role of surfactant proteins in the pathogenesis of allergen-induced airway inflammation has not been elucidated. In this study we examined the levels and distributions of SP-A and SP-D in a dust mite (Dermatophagoides pteronyssinus, Der p) allergen-induced murine model of asthma. ⋯ These results indicated the involvement of pulmonary surfactant proteins in the allergic bronchial inflammation of sensitized mice.