Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
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Comparative Study
Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy.
During the last decade, evidence has been provided for profilins and cross-reactive carbohydrate determinants (CCDs) to be capable of inducing cross-reactive IgE antibodies with little clinical relevance. ⋯ Patients monoallergic to NRL or birch pollen showed no sensitization to bromelain-type CCD or profilin. Sensitization to profilin and/or bromelain-type CCD, caused by pollen (timothy grass, mugwort) or hymenoptera venom allergens, can elicit false-positive IgE antibodies against NRL and apple.