Journal of psychopharmacology
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J. Psychopharmacol. (Oxford) · Apr 2019
Clinical TrialInvestigation of medical effect of multiple ketamine infusions on patients with major depressive disorder.
Single-dose intravenous ketamine has rapid but time-limited antidepressant effects. We aimed to examine the sustained effects of six consecutive ketamine infusions in Chinese patients with major depressive disorder. ⋯ Six ketamine infusions increased rates of response and remission when compared to a single-dose ketamine infusion in patients with major depressive disorder. Future controlled studies are warranted to confirm and expand these findings.