Journal of psychopharmacology
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J. Psychopharmacol. (Oxford) · Sep 2019
Prevalence and epidemiological associates of novel psychedelic use in the United States adult population.
Novel psychedelics approximate classic psychedelics, but unlike classic psychedelics, novel psychedelics have been used by humans for a shorter period of time, with fewer data available on these substances. ⋯ Novel psychedelics may differ from classic psychedelics in meaningful ways, though additional, directed research is needed.
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J. Psychopharmacol. (Oxford) · Sep 2019
Meta AnalysisCessation and reduction in alcohol consumption and misuse after psychedelic use.
Meta-analysis of randomized studies using lysergic acid diethylamide (LSD) for alcohol use disorder (AUD) showed large, significant effects for LSD efficacy compared to control conditions. Clinical studies suggest potential anti-addiction effects of LSD and mechanistically-related classic psychedelics for alcohol and other substance use disorders. ⋯ Although results cannot demonstrate causality, they suggest that naturalistic psychedelic use may lead to cessation or reduction in problematic alcohol use, supporting further investigation of psychedelic-assisted treatment for AUD.
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J. Psychopharmacol. (Oxford) · Sep 2019
ReviewMicrodosing psychedelics: More questions than answers? An overview and suggestions for future research.
In the past few years, the issue of 'microdosing' psychedelics has been openly discussed in the public arena where claims have been made about their positive effect on mood state and cognitive processes such as concentration. However, there are very few scientific studies that have specifically addressed this issue, and there is no agreed scientific consensus on what microdosing is. ⋯ It is concluded that while most anecdotal reports focus on the positive experiences with microdosing, future research should also focus on potential risks of (multiple) administrations of a psychedelic in low doses. To that end, (pre)clinical studies including biological (e.g. heart rate, receptor turnover and occupancy) as well as cognitive (e.g. memory, attention) parameters have to be conducted and will shed light on the potential negative consequences microdosing could have.