Journal of psychopharmacology
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J. Psychopharmacol. (Oxford) · Oct 2020
Microdosing psychedelics: Subjective benefits and challenges, substance testing behavior, and the relevance of intention.
Microdosing psychedelics is the practice of taking small, sub-hallucinogenic doses of lysergic acid diethylamide or psilocybin-containing mushrooms. Despite its surging popularity, little is known about the specific intentions to start microdosing and the effects of this practice. ⋯ Our results suggest the perceived benefits associated with microdosing greatly outweigh the challenges. Microdosing may have utility for a variety of uses while having minimal side effects. Double-blind, placebo-controlled experiments are required to substantiate these reports.
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J. Psychopharmacol. (Oxford) · Oct 2020
Risk of incident dementia in late-life depression treated with antidepressants: A nationwide population cohort study.
Antidepressants are frequently used to treat depression in patients with dementia. In addition, late-life depression is associated with the incidence of subsequent cognitive impairment or dementia. However, the association between exposure to antidepressants in late-life depression and the development of incident dementia remains understudied. ⋯ Antidepressants did not increase the risk of incident dementia in patients with late-life depression.