Respiratory medicine
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Respiratory medicine · Jan 2009
Randomized Controlled Trial Multicenter Study Comparative StudyThe efficacy of tiotropium administered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients.
Tiotropium, a once daily inhaled anticholinergic delivered via HandiHaler, provides bronchodilation for >24h and improves patient-centred outcomes. The Respimat Soft Mist Inhaler (SMI), a novel, propellant-free inhaler, has been developed and proposed as an alternative delivery device for use with tiotropium. ⋯ Tiotropium 5 microg Respimat SMI is comparable with tiotropium 18 microg HandiHaler in terms of efficacy, pharmacokinetics and safety. Respimat SMI is an effective alternative, multi-dose delivery device for tiotropium.