Respiratory medicine
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Respiratory medicine · Feb 2014
Review Meta AnalysisNocturnal noninvasive positive pressure ventilation in stable COPD: a systematic review and individual patient data meta-analysis.
The effects of nocturnal noninvasive positive pressure ventilation (NIPPV) in patients with stable chronic obstructive pulmonary disease (COPD) remain controversial. ⋯ At present, there is insufficient evidence to support the application of routine NIPPV in patients with stable COPD. However, higher IPAP levels, better compliance and higher baseline PaCO2 seem to improve PaCO2.
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Respiratory medicine · Feb 2014
Meta AnalysisPooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD.
This post-hoc analysis examined the impact of roflumilast on chronic obstructive pulmonary disease (COPD) exacerbations and lung function in patients with COPD who received concomitant long-acting β2-agonists (LABA) with or without prior inhaled corticosteroid (ICS) and the influence of various demographic and clinical characteristics on these outcomes. ⋯ NCT00297102 (M2-124) and NCT00297115 (M2-125).
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Respiratory medicine · Feb 2014
Randomized Controlled TrialContrasting breathing retraining and helium-oxygen during pulmonary rehabilitation in COPD: a randomized clinical trial.
Breathing-retraining and helium-oxygen (heliox) have been used to improve exercise tolerance in COPD. We hypothesized that, in patients with COPD, exercise duration after exercise-training plus breathing-retraining and oxygen would be longer than after exercise-training plus heliox or after exercise-training plus oxygen alone. We also explored the short-term maintenance of gains in exercise duration after using each technique. ⋯ In moderate-to-severe COPD, exercise-training combined with either heliox or with breathing-retraining yielded not significantly different improvements in exercise duration - with only the latter being superior to exercise-training. Six-weeks after training, these improvements were still greater after exercise-training plus breathing-retraining than after exercise-training.
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Respiratory medicine · Feb 2014
Mortality in non-cystic fibrosis bronchiectasis: a prospective cohort analysis.
There is limited data on mortality and associated morbidity in non-cystic fibrosis bronchiectasis (NCFB). Our aim was to analyze the overall mortality for all newly diagnosed patients from June 2006 onwards and to evaluate risk factors for mortality in this cohort. ⋯ NCFB patients with associated COPD disease had the highest mortality rates compared to the other NCFB patients. Additional risk factors for lower survival were increasing age and number of lobes affected.