Respiratory medicine
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Respiratory medicine · Oct 2015
Randomized Controlled TrialTiotropium + olodaterol shows clinically meaningful improvements in quality of life.
Tiotropium + olodaterol improves lung function and symptoms compared to monotherapies in chronic obstructive pulmonary disease (COPD). The OTEMTO 1 and 2 studies investigated the effects of tiotropium + olodaterol on lung function and health-related quality of life compared to placebo in patients with moderate to severe COPD. ⋯ Tiotropium + olodaterol improved lung function and quality of life compared to placebo and tiotropium 5 μg.
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Respiratory medicine · Oct 2015
Mayo clinic experience of lung transplantation in pulmonary lymphangioleiomyomatosis.
Lymphangioleiomyomatosis (LAM) is a rare, cystic lung disease that generally results in progressive decline in lung function. Despite advancement of pharmacological therapy for LAM, lung transplantation remains an important option for women with end-stage LAM. ⋯ Lung transplant remains a viable treatment for patients with end-stage LAM. The role of sirolimus peri-transplantation remains ill-defined.