Respiratory medicine
-
Respiratory medicine · Jan 2018
ReviewWeaning failure and respiratory muscle function: What has been done and what can be improved?
Respiratory muscle dysfunction, being a common cause of weaning failure, is strongly associated with prolonged mechanical ventilation (MV) and prolonged stay in intensive care units. Inspiratory muscle training (IMT) has been described as an important contributor to the treatment of respiratory muscle dysfunction in critically ill patients. Its effectiveness is however yet controversial. ⋯ Methods to indentify respiratory muscle weakness in critically ill patients are feasible and described as indexes that show good accuracy. Individualized and supervised rehabilitation programs including IMT, SBT, noninvasive MV and early mobilization should be encouraged in patients with inspiratory muscle weakness.
-
Respiratory medicine · Jan 2018
Multicenter StudyRisk factors for nosocomial infection among hospitalised severe influenza A(H1N1)pdm09 patients.
Nosocomial infections following influenza are important causes of death, requiring early implementation of preventive measures, but predictors for nosocomial infection in the early stage remained undetermined. We aimed to determine risk factors that can help clinicians identify patients with high risk of nosocomial infection following influenza on admission. ⋯ Need for mechanical ventilation, sepsis, ICU admission on first day, lymphocytopenia, older age and anaemia were independent risk factors that can help clinicians identify severe influenza A(H1N1)pdm09 patients at high risk of nosocomial infection.
-
Respiratory medicine · Jan 2018
Clinical TrialBaseline serum CXCL10 and IL-12 levels may predict severe asthmatics' responsiveness to omalizumab.
Omalizumab, a humanized anti-IgE monoclonal antibody, is the first molecularly targeted drug for severe asthmatics. However, responses to omalizumab vary widely among patients. ⋯ High baseline serum CXCL10 and IL-12 levels may be useful in predicting a good omalizumab response in severe asthmatics.
-
Respiratory medicine · Jan 2018
Evaluation of a respiratory symptom diary for clinical studies of idiopathic pulmonary fibrosis.
There are no validated patient diaries for evaluating respiratory symptoms in idiopathic pulmonary fibrosis (IPF). ⋯ The E-RS™: IPF is a valid, reliable, and responsive tool for evaluating respiratory symptoms in patients with IPF.
-
Respiratory medicine · Jan 2018
Several high-resolution computed tomography findings associate with survival and clinical features in rheumatoid arthritis-associated interstitial lung disease.
To compare the presence and extent of several high-resolution computed tomography (HRCT) observations in different subtypes of rheumatoid arthritis-related interstitial lung disease (RA-ILD) and to examine associations between radiological findings, hospitalization, age, RA duration, pulmonary function tests (PFT) and survival. ⋯ Many radiological findings associate with the course of the disease of RA-ILD and could potentially be useful when planning the RA treatment or evaluating the risk of death in these patients.