Respiratory medicine
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Respiratory medicine · Feb 2006
Randomized Controlled TrialEffect of formoterol/budesonide combination on arterial blood gases in patients with acute exacerbation of COPD.
Patients with severe chronic airway obstruction might suffer dangerous hypoxemia after administration of a beta-agonist despite bronchodilation. ⋯ These results suggest that when treating patients suffering from acute exacerbation of COPD with formoterol, it is prudent to check their arterial blood gases. In any case, combined administration of formoterol and budesonide reduces the potential for acute effects of formoterol on blood-gas tensions.
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Respiratory medicine · Feb 2006
Prevalence and underdiagnosis of COPD by disease severity and the attributable fraction of smoking Report from the Obstructive Lung Disease in Northern Sweden Studies.
There is a lack of epidemiological data on COPD by disease severity. We have estimated the prevalence and underdiagnosis of COPD by disease severity defined by the British Thoracic Society (BTS) and Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. The impact of smoking was evaluated by the population attributable fraction of smoking in COPD. ⋯ Most subjects with COPD have a mild disease. The underdiagnosis is related to disease-severity. Though being symptomatic, only a half of the subjects with severe COPD are properly labelled. Smoking and increasing age were the major risk factors and acted synergistic.
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Respiratory medicine · Jan 2006
Randomized Controlled Trial Comparative StudyTwo different training programmes for patients with COPD: a randomised study with 1-year follow-up.
To compare the effects on exercise capacity and health related quality of life (HRQoL) of two exercise programmes; one programme including endurance training and one including only resistance training and callisthenics. A second purpose was to find out whether the severity of chronic obstructive pulmonary disease (COPD) affected the training response and whether the interventions had a long-term effect. ⋯ Exercise capacity in patients with severe and moderate COPD improved by intensive endurance training, two sessions a week for 8 weeks. The improvement was however small and HRQoL did not improve. Severity of illness did not affect response to training. The results indicated that the effects of a short endurance training intervention slowed down decline in baseline functional exercise capacity for 1 year.
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Respiratory medicine · Jan 2006
Predictors of hospital outcome and intubation in COPD patients admitted to the respiratory ICU for acute hypercapnic respiratory failure.
Mortality rate, the possible factors affecting mortality and intubation in patients with acute exacerbation of chronic obstructive pulmonary diseases (COPD) and hypercapnic respiratory failure (RF) are yet unclear. ⋯ The most important predictors related to hospital mortality were the need for invasive ventilation and complications to MV. Adequate metabolic compensation for respiratory acidosis at admittance is associated with better survival. A high APACHE II score and loss of consciousness (low GCS) were independent predictors of a need to intubate patients.
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Respiratory medicine · Jan 2006
Global Initiative on Obstructive Lung Disease (GOLD) classification of lung disease and mortality: findings from the Atherosclerosis Risk in Communities (ARIC) study.
To determine whether a modified Global Initiative on Obstructive Lung Diseases (GOLD) classification of chronic obstructive pulmonary disease (COPD) predicts mortality in a cohort of subjects followed for up to 11 years. ⋯ The modified GOLD classification system of COPD predicts mortality in this cohort of middle-aged Americans followed for up to 11 years.