Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol
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J Neurosurg Anesthesiol · Oct 2013
Clonidine induces sedation through acting on the perifornical area and the locus coeruleus in rats.
The main target site of action for the sedative clonidine (CLO), an α2 adrenoceptor agonist, has been considered to be the locus coeruleus (LC). However, previous reports suggest other sites of action of CLO than the LC. Our previous studies suggested that the neuronal activities in the perifornical area (Pef) could influence the sedative or the anesthetic level induced by anesthetics. Therefore, we examined whether microinjection of CLO into the Pef might induce sedation in rats. ⋯ The Pef and the LC are responsible for the sedative action of CLO in rats.