Journal of clinical pharmacology
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Comparative Study Clinical Trial Controlled Clinical Trial
Analgesic comparison of propiram fumarate with pentazocine, codeine, and placebo in postsurgical pain.
The safety and effectiveness of a single oral dose of 50 mg propiram fumarate as an analgesic was compared in a double-blind clinical trial trial against single doses of standard reference analgesics (50 mg pentazocine hydrochloride or 60 mg codeine sulfate) or placebo. Subjects were adult patients experiencing severe postsurgical pain. ⋯ These were not severe enough to require treatment. Propiram fumarate (50 mg) was shown to be an effective and safe analgesic in the treatment of severe postsurgical pain.