Journal of clinical pharmacology
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Comparative Study Clinical Trial
Clinical comparison of zomepirac with APC/codeine combination in the treatment of pain following oral surgery.
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Comparative Study Clinical Trial
Clinical evaluation of zomepirac and APC with codeine in the treatment of postpartum episiotomy pain.
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Clinical Trial Controlled Clinical Trial
Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain.
A twin crossover assay of oral zomepirac and intramuscular morphine was completed in 159 cancer patients with postoperative pain. Zomepirac was a surprisingly effective oral analgesic in these patients, 100 mg orally being roughly equivalent to 16 mg intramuscular morphine. ⋯ Side effect occurrence was roughly in the same range for both drugs, with drowsiness, nausea, dry mouth, and feelings of weakness being observed after both drugs while sweating was observed more frequently after zomepirac. The assay further provided a demonstration of the effectiveness of the twin crossover design as a clinical assay method, providing increased sensitivity of crossover data in a patient population available for only a limited number of study treatments.
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Comparative Study Clinical Trial
Comparison of zomepirac, APC with codeine, codeine and placebo in the treatment of moderate and severe postoperative pain.